2026.1-今??中國科學院廣州生物醫(yī)藥與健康研究院，廣州，研究員/課題組長
2022.2-2025.12??復旦大學，生物醫(yī)學研究院，上海，青年研究員
2018.3-2022.1???上海交通大學醫(yī)學院，精準醫(yī)學研究院，上海，助理/副研究員
2013.8-2017.11??馬克斯-普朗克生物化學研究所，德國慕尼黑，博士
2006.9-2013.7???山東大學生命科學學院，山東濟南，學士/碩士
研究方向聚焦于真核生物轉錄調控相關復合物的結構與功能研究，特別關注與腫瘤發(fā)生發(fā)展密切相關的、調控轉錄活性的重要蛋白質復合物。迄今，以并列/第一作者或者通訊作者在Nature、 Science、 Nature Structural & Molecular Biology、 Cell Research、 Nature Communications、 PNAS 等國際高影響力期刊發(fā)表研究論文數(shù)十篇。研究工作得到國家自然科學基金面上項目和青年項目等資助，入選上海市浦江人才計劃。
研究組將圍繞“非編碼RNA的動態(tài)特征與功能機制”這一核心，開展以下三個層次的研究：首先，在多尺度上解析其轉錄與加工的動態(tài)特征；其次，揭示其參與形成的功能網絡與調控機制；最終，基于上述發(fā)現(xiàn)，致力于開發(fā)基于RNA的精準診斷方法與治療靶點。
2025-2029 國家自然科學基金面上項目
2020-2022 國家自然科學基金青年項目
2019-2021 上海市浦江人才計劃項目（A類）
2015年度國家優(yōu)秀自費留學生獎學金
2021年上海交通大學醫(yī)學院“九龍醫(yī)學優(yōu)秀青年人才獎”
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2. Wang Q*, Li S*, Wan F*, Xu Y*, Wu Z, Cao M, Lan P#, Lei M#, Wu J#. Structural insight into transcription regulation of human RNA polymerase III. Nature Structural&Molecular Biology, 2021, 28:220-227
3. Wang Q, Taschner M, Ganzinger K, Kelley C, Villasenor A, Heymann M, Schwille P, Lorentzen E, Mizuno N. Membrane association and remodeling by intraflagellar transport protein IFT172. Nature communications, 2018, 9(1)
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5. Chen X*, Liu W*, Wang Q*, Wang X*, Ren Y, Qu X, Li W, Xu Y. Structural visualization of transcription initiation in action. Science, 2023, 382(6677):eadi5120
6. Li Y*, Wang Q*, Xu Y, Li Z. Structures of co-transcriptional RNA capping enzymes on paused transcription complex. Nature Communications, 2024, 15(1):4622
7. Wan F*, Wang Q*, Tan J*, Tan M, Chen J, Shi S, Lan P#, Wu J #, Lei M #. Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme. Nature communications, 2019,10(1)
8. Chen K*, Wang L*#, Yu Z*, Yu J, Ren Y, Wang Q#, Xu Y#. Structure of the human TIP60 complex. Nature Communications, 2024, 15(1):7092
9. Hou H*, Jin Q*, Ren Y*, Chen Z, Wang Q#, Xu Y#. Structure of the SNAPc-bound RNA polymerase III preinitiation complex. Cell Research, 2023, 33(7):565-568
10. Wang L*, Yu J*, Yu Z*, Wang Q*, Li W, Ren Y, Chen Z#, He S#, Xu Y#. Structure of nucleosome-bound human PBAF complex. Nature Communications, 2022, 13(1):7644
11. Wang Q, Lei M, Wu J. A structural perspective of human RNA polymerase III. RNA Biology, 2022, 19(1):246-255
12. Wang Q*, Daiss L J*, Xu Y#, Engle C#. Snapshots of RNA polymerase III in action-a mini review. Gene, 2022, 821:146282
13. Su H*, Wang Q*, Li C, Li K, Luo W, Chen B, Zhang X, Qin Q, Zhou B, Chen X, Zhang Y, Xie B. Structural insights into the cold adaptation of the photosynthetic pigment-protein C-phycocyanin from an Arctic cyanobacterium. Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2017, 1858(4): 325-335
14. Wu J*, Niu S*, Tan M*, Huang C, Li M, Song Y, Wang Q, Chen J, Shi S, Lan P#, Lei M#. Cryo-EM structure of the human ribonuclease P holoenzyme. Cell, 2018, 175(5):1393-1404
15. Yao T, Jing W, Hu Z, Tan M, Cao M, Wang Q, Li Y, Yuan G, Lei M, Huang J. Structural basis of the crosstalk between histone H2B monoubiquitination and H3 lysine 79 methylation on nucleosome. Cell Research, 2019, 29(4):330-333
